Pabitra Kumar Sahoo

A CK2α-G3BP1 signaling axis regulates local translation in developing neurons and is disrupted in OCNDS

This study identifies a CK2α-G3BP1 signaling axis critical for neuronal translation and development, showing its disruption causes OCNDS pathology.

Multiple mTOR RNA localization signals regulate subcellular protein synthesis and axonal growth

The paper identifies multiple mTOR RNA localization signals in the 5'UTR and 3'UTR that regulate subcellular mTOR localization, protein synthesis, and axonal growth in mice.

Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration

This study shows that acetylation of G3BP1 by ELP3 promotes axon regeneration and neuronal recovery after injury.

Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndrome

Disruption of G3BP1 Granules Promotes Mammalian CNS and PNS Axon Regeneration

This paper shows that disrupting G3BP1 granules promotes axon regeneration in both CNS and PNS injuries, suggesting a therapeutic strategy for neural repair.

Dynamic Effects of Ventral Hippocampal NRG3/ERBB4 Signaling on Nicotine Withdrawal-Induced Responses

This study investigates the role of NRG3-ERBB4 signaling in the ventral hippocampus during nicotine withdrawal, showing its impact on anxiety-like behaviors and synaptic function.

PTBP1 Regulates Injury Responses and Sensory Pathways in Adult Peripheral Neurons

This study shows PTBP1 is expressed in adult sensory and motor neurons, with increased axonal levels after injury, affecting axon outgrowth and sensation.

Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs

This study identifies KHSRP as an axonal RNA-binding protein whose mRNA is locally translated after nerve injury, leading to mRNA destabilization and slowed axon regeneration.

Selective axonal translation of prenylated Cdc42 mRNA isoform supports axon growth

The paper shows that prenyl-Cdc42 mRNA localizes to PNS axons and promotes axon growth through localized translation and prenylation.