Inhibition of p107 alleviates liver steatosis by reducing de novo fatty acid synthesis.
Juan Cuñarro, Marta Varela Miguens, Tadeu de Oliveira Diz, Xabier Buqué, Lucia Oro, Cristina Riobello, Jose Iglesias-Moure, Carmen Quintela-Vilariño, Ana T. Maduro, Alba Cabaleiro, Eva Nóvoa, Alejandro Fuentes-Iglesias, Miguel Fidalgo, Diana Guallar, Anxo Vidal, , Sulay A. Tovar
This study shows that inhibiting p107 reduces liver steatosis by lowering de novo fatty acid synthesis and enhancing mitochondrial function in both mouse models and human hepatocytes.
bioRxiv · Apr 16, 2026 · PreprintPhysiology