Miguel Fidalgo

This study shows that GEN1 is essential for mouse embryonic stem cell self-renewal and genome stability, with a non-enzymatic role in maintaining pluripotency.

This study shows that inhibiting p107 reduces liver steatosis by lowering de novo fatty acid synthesis and enhancing mitochondrial function in both mouse models and human hepatocytes.

This study shows rapamycin reverses gene expression in Ccm3-deficient endothelial cells and, when combined with lapatinib, reduces lesion volume in a chronic CCM model.

This study shows astrocytic AMPK links metabolic signals to hypothalamic circadian timing by regulating phosphoproteome organization and behavior.