The intrinsically disordered region of the E3 ubiquitin ligase TRIP12 induces the formation of chromatin condensates and interferes with DNA damage response.
Claire Vargas, Manon Brunet, Alban Ricard, Damien Varry, Dorian Larrieu, Fernando Muzzopappa, Fabian Erdel, Guillaume Labrousse, Naïma Hanoun, Lætitia Ligat, Manon Farcé, Alexandre Stella, Odile Burlet‐Schiltz, Henrik Laurell, Nicolas Béry, , Jérôme Torrisani
This study shows TRIP12's intrinsically disordered region drives chromatin condensate formation, disrupting DNA damage response and genome accessibility.
bioRxiv · Sep 13, 2023 · PreprintMolecular Biology