Semirandom DNA adducts regulate a filamentous defence-associated reverse transcriptase
Nolan Neville, Nicole V. Johnson, Edwin E. Escobar, Chang-Hwa Chiang, Albana Nreca, Sean R. Johnson, Nan Dai, Andy Hanneman, Ivan Reis Correa Junior, Jason S. McLellan, Robert J. Trachman
This study characterizes the DRT1 antiphage defence system, showing it generates semirandom DNA adducts that regulate filament assembly and function through structural changes.
bioRxiv · Mar 9, 2026 · PreprintMicrobiology