Nan Dai

This study shows that HPAMPD deaminates RNA adenosines preferentially at terminal ends and in loop regions, influenced by structural features like base pairing and magnesium-dependent folding.

This study characterizes the DRT1 antiphage defence system, showing it generates semirandom DNA adducts that regulate filament assembly and function through structural changes.

The paper identifies key players in the 2,6-diaminopurine biosynthesis pathway using metagenomic data from aquatic environments.

The paper discovers novel DNA cytosine deaminases and develops a nondestructive single-enzyme methylation sequencing method for high-coverage methylome mapping of low-input DNA.

This study evaluates the fidelity of uridine analog incorporation during in vitro transcription using different RNA polymerases and introduces a protocol to improve incorporation fidelity without affecting RNA yield.

This study introduces MetaGPA, a framework linking metagenomic genetic data to functional phenotypes, and identifies a novel cytosine modification mechanism in DNA and RNA.

EM-seq detects DNA methylation at single base resolution using less DNA than bisulfite sequencing, showing improved accuracy and reliability.

This paper introduces LR-EM-seq, an enzymatic deamination method for long-range methylation profiling of 5-mC and 5-hmC, achieving better-defined DMRs over 5 kb.

This study characterizes the yeast DcpS enzyme's ability to decap long RNA transcripts and validates its use for enriching capped RNA through a tagging strategy.