Ivan Reis Correa Junior

This study identifies NSP14's role in inducing internal m7G modification in host mRNA, disrupting splicing and promoting SARS-CoV-2 replication, with implications for therapeutic targeting.

This study characterizes the DRT1 antiphage defence system, showing it generates semirandom DNA adducts that regulate filament assembly and function through structural changes.

The paper identifies key players in the 2,6-diaminopurine biosynthesis pathway using metagenomic data from aquatic environments.

This paper demonstrates the use of Mpa Ago for in vitro mRNA processing and analysis, including 3' end polishing and comprehensive assessment of mRNA features using LC-MS/MS.

The paper discovers novel DNA cytosine deaminases and develops a nondestructive single-enzyme methylation sequencing method for high-coverage methylome mapping of low-input DNA.

This study introduces NRCeq, a method to identify capped full-length SARS-CoV-2 transcripts, revealing new insights into sgRNA structure and expression.

This study introduces MetaGPA, a framework linking metagenomic genetic data to functional phenotypes, and identifies a novel cytosine modification mechanism in DNA and RNA.

The paper identifies high-confidence full-length human RNA isoform scaffolds using nanopore sequencing by improving 5' cap detection and 3' polyadenylation site identification.

EM-seq detects DNA methylation at single base resolution using less DNA than bisulfite sequencing, showing improved accuracy and reliability.

This study performs a GWAS on random glucose measurements in 493,036 individuals, identifying 128 loci associated with glycaemic traits and providing insights into diabetes biology and treatment.

This paper introduces LR-EM-seq, an enzymatic deamination method for long-range methylation profiling of 5-mC and 5-hmC, achieving better-defined DMRs over 5 kb.

This study characterizes the yeast DcpS enzyme's ability to decap long RNA transcripts and validates its use for enriching capped RNA through a tagging strategy.

This paper introduces SYNseq, a method using barcode sequencing to map neural connectomes efficiently, though current inefficiencies limit its application.