A Scube2-Shh feedback loop links morphogen release and spread to morphogen signaling to enable scale invariant patterning of the ventral neural tube
Zach M. Collins, Anna Cha, Albert Qin, Kana Ishimatsu, Tony Yu-Chen Tsai, Ian A. Swinburne, Pulin Li, Sean G. Megason
The paper shows that Scube2 and Shh form a feedback loop that enables the Shh morphogen gradient to scale with tissue size in the ventral neural tube.
bioRxiv · Jul 3, 2023 · PreprintDevelopmental Biology