Tony Yu-Chen Tsai

The paper shows that cells specify fate within an optimal window of positional information during zebrafish neurulation, where Shh gradient information peaks early and declines despite increasing signal activity.

The paper shows intermediate spinal cord progenitors are specified through neural plate dynamics and signaling, not direct morphogen exposure.

The paper shows that Scube2 and Shh form a feedback loop that enables the Shh morphogen gradient to scale with tissue size in the ventral neural tube.

The paper shows that hyaluronate pressure, driven by local secretion and anisotropic tissue stiffness, shapes zebrafish semicircular canals without actomyosin contractility.

The paper identifies an adhesion code in zebrafish neural progenitors that ensures robust stripe-like pattern formation during spinal cord morphogenesis.

The paper identifies a pressure relief valve in the endolymphatic sac of zebrafish larvae that regulates inner ear pressure through dynamic lamellar junctions.