Zach M. Collins

A Scube2-Shh feedback loop links morphogen release and spread to morphogen signaling to enable scale invariant patterning of the ventral neural tube

The paper shows that Scube2 and Shh form a feedback loop that enables the Shh morphogen gradient to scale with tissue size in the ventral neural tube.

Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms

The paper develops a method to image subcellular dynamics in vivo using lattice light sheet microscopy and adaptive optics, revealing phenotypic diversity across organisms and developmental stages.

Size-reduced embryos reveal a gradient scaling based mechanism for zebrafish somite formation

The paper shows that a dynamically scaling gradient in the presomitic mesoderm regulates somite size control in zebrafish embryos.