Author

Anna Cha

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genetics· 1

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1

Frequent Co-Authors

Sean G. MegasoniD· 2 shared Tony Yu-Chen TsaiiD· 2 shared Albert Qin· 1 shared Angela H. DePaceiD· 1 shared Ben J. VincentiD· 1 shared Bill JiaiD· 1 shared Caroline ComenhoiD· 1 shared Chiara Ricci-TamiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

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10 top collaborators · 20 mutual co-author links

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2 shared papersDevelopmental Biology

Sean G. MegasonORCID

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3 papers

Recent·Most cited

Neural plate morphogenesis and pre-patterning enable specification of intermediate progenitors in the spinal cord

Nagarajan Nandagopal, Anna Cha, Bill Jia, Hongyu Liao, Caroline Comenho, Galit Lahav, Daniel E. Wagner, Tony Yu-Chen Tsai, Sean G. Megason

The paper shows intermediate spinal cord progenitors are specified through neural plate dynamics and signaling, not direct morphogen exposure.

bioRxiv · Jan 9, 2025 · PreprintDevelopmental Biology

A Scube2-Shh feedback loop links morphogen release and spread to morphogen signaling to enable scale invariant patterning of the ventral neural tube

Zach M. Collins, Anna Cha, Albert Qin, Kana Ishimatsu, Tony Yu-Chen Tsai, Ian A. Swinburne, Pulin Li, Sean G. Megason

The paper shows that Scube2 and Shh form a feedback loop that enables the Shh morphogen gradient to scale with tissue size in the ventral neural tube.

bioRxiv · Jul 3, 2023 · PreprintDevelopmental Biology

Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

Jeehae Park, Javier Estrada, Gemma Johnson, Ben J. Vincent, Chiara Ricci-Tam, Meghan D. J. Bragdon, Yekaterina Shulgina, Anna Cha, Zeba Wunderlich, Jeremy Gunawardena, Angela H. DePace

The paper investigates the HbP2 enhancer in Drosophila, showing that cooperative binding of Bcd is insufficient to explain its sharp expression pattern, and identifies other factors like pioneer factors and histone modifiers as key contributors.

eLife · Jun 21, 2019Peer-reviewedGenetics