Luca Maragliano

Controlled Blood-Brain Barrier Modulation by a High-Affinity Claudin-5 Peptide Binder

The paper designs a high-affinity CLDN5 peptide binder, ST9, that induces reversible, size-controlled BBB openings without altering CLDN5 expression or proteomic profile.

Molecular mechanism of partially open Kv7.2 gate stabilization by gain-of-function variants

This study investigates how gain-of-function variants in the Kv7.2 channel's activation gate stabilize a partially open conformation, enabling K+ permeation and linking it to neurodevelopmental disorders.

A multi-pore model of the blood-brain barrier tight junction strands recapitulates the permeability features of wild-type and mutant claudin-5

The paper models the blood-brain barrier tight junctions using multi-pore structures and shows that multi-Pore I replicates the permeability effect of a Cldn5 mutation.

A claudin5-binding peptide enhances the permeability of the blood-brain-barrier

The paper designs and tests peptides that bind claudin-5 to increase blood-brain barrier permeability, identifying a peptide that effectively enhances permeability in vitro.

CONSTITUTIVE OPENING OF THE Kv7.2 PORE ACTIVATION GATE CAUSES KCNQ2-DEVELOPMENTAL ENCEPHALOPATHY

This study identifies two KCNQ2 variants causing developmental encephalopathies by constitutively opening the Kv7.2 pore activation gate, leading to gain-of-function effects.

Ion and water permeation through Claudin-10b paracellular channels

This study uses Molecular Dynamics simulations to compare ion and water permeability of Cldn10b and Cldn15 paracellular channels, revealing structural determinants of their permeability properties.

The Impact of Pathogenic and Artificial Mutations on Claudin-5 Selectivity from Molecular Dynamics Simulations

The paper uses molecular dynamics simulations to study how pathogenic and artificial mutations affect ion selectivity in Claudin-5 paracellular pores, identifying structural models that align with experimental observations.

In silico conformational features of botulinum toxins A1 and E1 according to the intraluminal acidification

This study uses molecular dynamics simulations to analyze conformational changes in botulinum toxins A1 and E1 under different pH conditions, revealing domain movements and structural dynamics.

Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood-Brain-Barrier Tight-Junctions

This study compares two structural models of Claudin-5 complexes in BBB tight junctions using molecular dynamics and free energy calculations to assess their ionic transport properties.

A Membrane-Targeted Photoswitch Potently Modulates Neuronal Firing

This paper describes a membrane-targeted photoswitch that modulates neuronal firing by altering membrane capacitance, without affecting ion channels or temperature.