VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment
Ruben I. Calderon, Nirvay Sah, Molly Huang, Sampada Kallol, Ryan Kittle, Walee Shaik, Ahmed Abdelbaki, Jennifer N. Chousal, Robert E. Morey, Tony Bui, Alejandra Mitre, Norah M. E. Fogarty, Claudia Gerri, Zoe Manalo, Claire Zheng, , Francesca Soncin
This study identifies VGLL1 as a key regulator of trophoblast development by integrating BMP, WNT, and HIPPO signaling through chromatin remodeling and transcriptional control in human stem cells.
Proceedings of the National Academy of Sciences · Nov 24, 2025Peer-reviewedDevelopmental Biology