Claudia Gerri

This study shows that oxygen levels and HIF1α act independently to regulate human trophoblast maturation and function in organoids.

This study identifies VGLL1 as a key regulator of trophoblast development by integrating BMP, WNT, and HIPPO signaling through chromatin remodeling and transcriptional control in human stem cells.

The paper investigates the role of YAP1 and TEAD1 in lineage segregation during human pre-implantation embryos, showing their involvement in trophectoderm and primitive endoderm formation independent of polarity.

The paper investigates the conservation of Hippo signaling in the first lineage specification event across four mammalian species, finding that inhibiting the Hippo pathway drives ectopic trophectoderm initiation in all species.

GIANI is an open-source software for automated analysis of 3D microscopy images, enabling segmentation, morphology quantification, and protein expression analysis in various imaging contexts.

The paper shows that Pdgfrb signaling is essential for mural cell development in zebrafish, similar to mice, and identifies context-dependent roles in vascular structures.

The paper shows that mutant mRNA degradation triggers transcriptional adaptation in zebrafish and mouse, leading to upregulation of related genes.

The paper identifies Npas4l target genes involved in cardiovascular development using zebrafish models and genome-wide approaches.