Francesca Soncin

Creatine phosphagen system regulates energy metabolism and growth of trophoblasts

This study investigates the role of the creatine phosphagen system in trophoblast development and shows that disrupting it impairs bioenergetics, proliferation, and survival.

VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment

This study identifies VGLL1 as a key regulator of trophoblast development by integrating BMP, WNT, and HIPPO signaling through chromatin remodeling and transcriptional control in human stem cells.

Single-cell transcriptomics reveal differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells

The paper uses single-cell RNA sequencing to compare transcriptional differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cells in early human placenta.

Human iPSC gene signatures and X chromosome dosage impact response to WNT inhibition and cardiac differentiation fate

The paper investigates how non-genetic variability in iPSC lines affects their response to WNT inhibition and cardiac differentiation, identifying 91 signature genes and X chromosome dosage differences as key factors.