Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse
Silvia Medrano, Lucas Ferreira de Almeida, Fernando Ruı́z-Pérez, Alejandro Gutierrez-Hernandez, Hiroki Yamaguchi, Daisuke Matsuoka, Manako Yamaguchi, Jason P. Smith, Thomas Wagamon, Maria Luisa S. Sequeira-Lόpez, R. Ariel Gómez
This paper describes a mouse model with a bright fluorescent reporter for renin-expressing cells, revealing renin hypomorphism and associated kidney dysfunction under RAS inhibition.
bioRxiv · May 2, 2025 · PreprintPhysiology