Hiroki Yamaguchi

This study investigates how AngII inhibits renin release in JG cell clusters through coordinated calcium oscillations, identifying key cellular mechanisms involved.

This study identifies renin-lineage cell fate reprogramming and metabolic dysfunction as drivers of concentric arterial hypertrophy, with potential biomarkers for early detection.

The paper maps interactions between renin cells and nerve fibers during kidney development and disease using single-cell RNA-Seq and imaging.

This paper describes a mouse model with a bright fluorescent reporter for renin-expressing cells, revealing renin hypomorphism and associated kidney dysfunction under RAS inhibition.

This paper develops an inducible mouse model to specifically control gene expression in renin cells, demonstrating efficient and targeted deletion of renin in adult mice without developmental effects.