Manako Yamaguchi

NetTracer3D Enables User-Friendly Analysis of Diverse Microscopic and Medical 3D Datasets

NetTracer3D provides a tool for analyzing 3D tissue maps from diverse datasets, enabling network-based exploration of spatial relationships and tissue organization.

Inhibition of Renin Release, a Crucial Event in Homeostasis, is Mediated by Coordinated Calcium Oscillations within Juxtaglomerular Cell Clusters.

This study investigates how AngII inhibits renin release in JG cell clusters through coordinated calcium oscillations, identifying key cellular mechanisms involved.

Hypoxia-Induced Metabolic Reprogramming and Markings of Cell Fate in Concentric Arterial Hypertrophy

This study identifies renin-lineage cell fate reprogramming and metabolic dysfunction as drivers of concentric arterial hypertrophy, with potential biomarkers for early detection.

Renin Cells Drive Kidney Neurovascular Development and Arterial Remodeling when Renin Activity is Deficient

The paper maps interactions between renin cells and nerve fibers during kidney development and disease using single-cell RNA-Seq and imaging.

Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse

This paper describes a mouse model with a bright fluorescent reporter for renin-expressing cells, revealing renin hypomorphism and associated kidney dysfunction under RAS inhibition.

An efficient inducible model for the control of gene expression in renin cells

This paper develops an inducible mouse model to specifically control gene expression in renin cells, demonstrating efficient and targeted deletion of renin in adult mice without developmental effects.