A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan
Lorna Jayne, Aurora J. Lavin-Peter, Julian M. Roessler, Alexander Tyshkovskiy, Mateusz Antoszewski, Erika Ren, Aleksandar Markovski, Senmiao Sun, Hanqi Yao, Vijay G. Sankaran, Vadim N. Gladyshev, Robert T. Brooke, Steve Horvath, Eric C. Griffith, Siniša Hrvatin
This study shows that inducing a torpor-like state in mice slows blood epigenetic aging and improves healthspan by reducing core body temperature.
Nature Aging · Mar 7, 2025Peer-reviewedPhysiology