Siniša Hrvatin

This study identifies a hypothalamic pathway involving ARCAgRP neurons and the MnPO that triggers energy conservation during fasting.

The paper identifies a neuronal population in the hypothalamic aPOA that controls hibernation entry in Syrian hamsters using single-nucleus RNA and chromatin profiling.

The paper identifies cis-regulatory elements for targeted gene delivery to nociceptors using multi-omic profiling and develops a sequence-based model to design synthetic enhancers.

The paper identifies a preoptic neurocircuit that modulates metabolic flexibility by shifting fuel use from glucose to fatty acids through insulin resistance in skeletal muscle.

This study delivers GJB2 specifically to target cells in mouse models of DFNB1 deafness, restoring hearing function and validating the approach in nonhuman primates.

This study shows that inducing a torpor-like state in mice slows blood epigenetic aging and improves healthspan by reducing core body temperature.

This study identifies cis-regulatory elements that drive motor neuron-specific gene expression in viral vectors, showing selectivity in mice and non-human primates.

This study identifies GPX4 as a conserved suppressor of cold-induced cell death through multi-species CRISPR screens in hibernators and non-hibernators.

The paper uses single-cell RNA sequencing to study how transcriptional changes during neurogenesis lead to the sequential generation of distinct septal neuron types.

PESCA identifies cell-type-specific enhancers using ATAC- and single-cell RNA-sequencing to generate viral reagents for targeted gene manipulation in mammalian cells.