Eric C. Griffith

This study identifies BAF complex interaction with FOS in regulating ASD-associated gene programs through enhancer activation and shows how genetic variants disrupt this process.

The paper identifies a neuronal population in the hypothalamic aPOA that controls hibernation entry in Syrian hamsters using single-nucleus RNA and chromatin profiling.

The paper identifies a preoptic neurocircuit that modulates metabolic flexibility by shifting fuel use from glucose to fatty acids through insulin resistance in skeletal muscle.

This study delivers GJB2 specifically to target cells in mouse models of DFNB1 deafness, restoring hearing function and validating the approach in nonhuman primates.

This study shows that ZMYND11 inhibits KMT2A to regulate neuronal development, and a mutation in ZMYND11 disrupts this interaction, leading to developmental and behavioral abnormalities.

The paper shows neuronal activity affects RNA stability, with HuD regulating mRNA abundance and variants linked to neurodevelopmental disorders disrupting this process.

This study identifies cell-type-specific chromatin accessibility and gene expression changes in the hippocampus following novel environment exposure using single-nucleus multiomics and bulk RNA-seq.

This study shows that inducing a torpor-like state in mice slows blood epigenetic aging and improves healthspan by reducing core body temperature.

This study identifies cis-regulatory elements that drive motor neuron-specific gene expression in viral vectors, showing selectivity in mice and non-human primates.

This study identifies GPX4 as a conserved suppressor of cold-induced cell death through multi-species CRISPR screens in hibernators and non-hibernators.

This study shows that activity-induced phosphorylation of MeCP2 is critical for retinogeniculate synapse maturation during early postnatal development.

This study maps RNA translation dynamics in the human brain using ribosome profiling, identifying thousands of novel translation events and brain-specific microproteins linked to schizophrenia.

PESCA identifies cell-type-specific enhancers using ATAC- and single-cell RNA-sequencing to generate viral reagents for targeted gene manipulation in mammalian cells.