Fasting reverses PLN R14del-mediated cardiomyopathy through lysosomal reactivation
Iris Gooijers, Aleksandra Arning, Cecilia de Heus, Ursula Heins-Marroquin, Phong D. Nguyen, Hessel Honkoop, Tim Verhagen, Mostafa M. Mokhles, Anneline S.J.M. te Riele, Magdaléna Harakaľová, Gijs W van Haaften, Linda Wilhelmina Van Laake, Lukas C. Kapitein, Nalan Liv, Jeroen Bakkers
This study shows that fasting improves PLN R14del cardiomyopathy by restoring lysosomal function and reducing SR-derived vesicle accumulation.
bioRxiv · Mar 26, 2026 · PreprintCell Biology