Author

Magdaléna Harakaľová

Utrecht UniversityORCID 0000-0002-7293-1029Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Renée G. C. MaasiD· 3 shared Alain van MiliD· 2 shared Eric VillardiD· 2 shared Folkert Wouter AsselbergsiD· 2 shared Frank G. van SteenbeekiD· 2 shared Joost P. G. SluijteriD· 2 shared Jorg J. A. CalisiD· 2 shared Linda Wilhelmina Van LaakeiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersGenomics

Renée G. C. MaasORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CardioShift: Resolving cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes from high-throughput single-cell imaging

Talitha C.F. Spanjersberg, C. Nina van der Wilt, Jung-Chin Chang, J Bernd Helms, Renee G.C. Maas, Joost P.G. Sluijter, Vincent Fontaine, Eric Villard, Teun P de Boer, Rogier J.A. Veltrop, Frank G van Steenbeek, Magdalena Harakalova

CardioShift resolves cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes by accounting for nested variance, revealing hidden subpopulations and condition-dependent phenotypes.

bioRxiv · Nov 3, 2026 · PreprintCell Biology

Fasting reverses PLN R14del-mediated cardiomyopathy through lysosomal reactivation

Iris Gooijers, Aleksandra Arning, Cecilia de Heus, Ursula Heins-Marroquin, Phong D. Nguyen, Hessel Honkoop, Tim Verhagen, Mostafa M. Mokhles, Anneline S.J.M. te Riele, Magdaléna Harakaľová, Gijs W van Haaften, Linda Wilhelmina Van Laake, Lukas C. Kapitein, Nalan Liv, Jeroen Bakkers

This study shows that fasting improves PLN R14del cardiomyopathy by restoring lysosomal function and reducing SR-derived vesicle accumulation.

bioRxiv · Mar 26, 2026 · PreprintCell Biology

Genome wide association analysis in dilated cardiomyopathy reveals two new key players in systolic heart failure on chromosome 3p25.1 and 22q11.23

Sophie Garnier, Magdaléna Harakaľová, Stefan Weiß, Michal Mokrý, Vera Regitz‐Zagrosek, Christian Hengstenberg, Thomas P. Cappola, Richard Isnard, Eloisa Arbustini, Stuart A. Cook, Jessica van Setten, Jorg J. A. Calis, Hakon H. Hakonarson, Michael P. Morley, Klaus J. Stark, , Philippe Charron

This study performs a large GWAS on dilated cardiomyopathy, identifying two new loci and confirming two existing ones, with potential therapeutic implications.

European Heart Journal · Jan 14, 2021Peer-reviewedGenomics

Transcriptional regulation profiling reveals disrupted lipid metabolism in failing hearts with a pathogenic phospholamban mutation

Jiayi Pei, Renée G. C. Maas, Ema Nagyova, Johannes M.I.H. Gho, C. Snijders Blok, Iris van Adrichem, Jorg J. A. Calis, René van Es, Shahrzad Sepehrkhouy, Dries A. M. Feyen, Noortje A. M. van den Dungen, Nico R. Lansu, Nicolaas de Jonge, Hester M. den Ruijter, Manon M. H. Huibers, , Magdaléna Harakaľová

The paper investigates epigenetic and transcriptional changes in PLN R14del cardiomyopathy, identifying disrupted lipid metabolism and altered gene regulation.

bioRxiv · Nov 30, 2020 · PreprintGenomics