Intramembrane protease SPPL2b deficiency linked to synaptic proteostasis remodeling with brain aging
Cristina Contini, Alessandra Schirru, Greca Lai, Giorgia Zodio, Jack Badman, Bjorn R. V. Bakker, Ylenia Lai, Per Nilsson, Giacomo Diaz, Tiziana Cabras, Simone Tambaro
This study shows that SPPL2b deficiency alters synaptic proteome and neuronal function in aging mice, with increased dendritic spine density and behavioral changes.
bioRxiv · Jul 28, 2026 · PreprintNeuroscience