Author

Simone Tambaro

Karolinska InstitutetORCID 0000-0001-7000-7556Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Per NilssoniD· 2 shared Alessandra Schirru· 1 shared André FisahniD· 1 shared Annika Wagener· 1 shared Bernd SchröderiD· 1 shared Bjorn R. V. Bakker· 1 shared Caterina Grassi· 1 shared Caterina Travisan· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Per NilssonORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 28, 2026

Intramembrane protease SPPL2b deficiency linked to synaptic proteostasis remodeling with brain aging

Cristina Contini, Alessandra Schirru, Greca Lai…·Simone Tambaro

This study shows that SPPL2b deficiency alters synaptic proteome and neuronal function in aging mice, with increased dendritic spine density and behavioral changes.

DOI 10.64898/2026.07.27.740894

mouseproteomics

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NeurosciencebioRxivPreprintOct 24, 2022

Signal Peptide Peptidase-Like 2b affects APP cleavage and exhibits a biphasic Aβ-mediated expression in Alzheimer's disease.

Riccardo Maccioni, Caterina Travisan, Stefania Zerial…·Simone Tambaro

This study shows that SPPL2b affects APP cleavage and has biphasic Aβ-mediated expression in Alzheimer's disease, suggesting it as a potential drug target.

1 citation

humanmouse

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