NeurosciencebioRxivPreprint
Intramembrane protease SPPL2b deficiency linked to synaptic proteostasis remodeling with brain aging
Cristina Contini, Alessandra Schirru, Greca Lai…·Simone Tambaro
This study shows that SPPL2b deficiency alters synaptic proteome and neuronal function in aging mice, with increased dendritic spine density and behavioral changes.
DOI 10.64898/2026.07.27.740894