Author

Greca Lai

University of CagliariORCID 0009-0002-6908-3433Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandra Schirru· 1 shared Bjorn R. V. Bakker· 1 shared Cristina ContiniiD· 1 shared Giacomo DiaziD· 1 shared Giorgia Zodio· 1 shared Jack BadmaniD· 1 shared Per NilssoniD· 1 shared Simone TambaroiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Alessandra Schirru

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1 paper

Recent·Most cited

Intramembrane protease SPPL2b deficiency linked to synaptic proteostasis remodeling with brain aging

Cristina Contini, Alessandra Schirru, Greca Lai, Giorgia Zodio, Jack Badman, Bjorn R. V. Bakker, Ylenia Lai, Per Nilsson, Giacomo Diaz, Tiziana Cabras, Simone Tambaro

This study shows that SPPL2b deficiency alters synaptic proteome and neuronal function in aging mice, with increased dendritic spine density and behavioral changes.

bioRxiv · Jul 28, 2026 · PreprintNeuroscience