Author

Jack Badman

Karolinska InstitutetORCID 0009-0008-5309-3470Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandra Schirru· 1 shared Bjorn R. V. Bakker· 1 shared Cristina ContiniiD· 1 shared Emilia KomulaineniD· 1 shared Giacomo DiaziD· 1 shared Giorgia Zodio· 1 shared Greca LaiiD· 1 shared Kate FennelliD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Alessandra Schirru

Mutual co-authors in cluster

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 28, 2026

Intramembrane protease SPPL2b deficiency linked to synaptic proteostasis remodeling with brain aging

Cristina Contini, Alessandra Schirru, Greca Lai…·Simone Tambaro

This study shows that SPPL2b deficiency alters synaptic proteome and neuronal function in aging mice, with increased dendritic spine density and behavioral changes.

DOI 10.64898/2026.07.27.740894

mouseproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 15, 2020

Aberrant PARP1 Activity Couples DNA Breaks to Deregulated Presynaptic Calcium Signalling and Lethal Seizures

Emilia Komulainen, Jack Badman, Stephanie A. Rey…·Keith W. Caldecott

This study shows that aberrant PARP1 activity at unrepaired DNA breaks causes deregulated presynaptic calcium signaling and lethal seizures in Xrcc1-defective mice, suggesting PARP inhibition as a therapeutic strategy.

2 citations

mouseexperimental assay

𝕏 PostBluesky