Impaired astrocyte-to-neuron cholesterol trafficking drives synaptic dysfunction in Rett syndrome
Francesca M Postogna, Noemi Giancroce, Cecilia Cabasino, Fabio Biella, Ottavia Maria Roggero, Martina Breccia, Laura Morelli, Diego Colombo, Alessandro Arcari, Giulia Lunghi, Manuela Valsecchi, Elena Chiricozzi, Nicoletta Landsberger, Marta Valenza, Angelisa Frasca
Mecp2 knock-out mouse astrocytes accumulate cholesterol yet release poorly lipidated ApoE; cholesterol supplementation restores synaptic puncta density in neurons exposed to their conditioned medium and in Mecp2 heterozygous neurons.
bioRxiv · Jul 31, 2026 · PreprintNeuroscience✦ In-depth digest