Francesca M Postogna

Mecp2 knock-out mouse astrocytes accumulate cholesterol yet release poorly lipidated ApoE; cholesterol supplementation restores synaptic puncta density in neurons exposed to their conditioned medium and in Mecp2 heterozygous neurons.

This study shows that neural precursor cell transplantation improves symptoms of Rett syndrome by activating the Interferon γ pathway.