Mechanobiology-guided drug repurposing identifies budesonide as an inhibitor of stiffness-induced PDAC aggressiveness
Simone Mas, Marco Cristiano, Eduardo Ibello, Alessandro Avallone, Crescenzo Frascogna, Bruno Sainz, Enza Lonardo, Lucia Altucci, Gilda Cobellis, Eduardo Jorge Patriarca, Paolo A. Netti, Gabriella Minchiotti, Valeria Panzetta, Cristina D’Aniello
This study identifies budesonide as a drug that inhibits stiffness-induced aggressiveness in pancreatic ductal adenocarcinoma by targeting mechanical cues.
bioRxiv · Jul 20, 2026 · PreprintBioengineering