Nuclear mechanostability emerges from satellite DNA condensation into chromocenters
Franziska Brändle, Benjamin Frühbauer, Ilaria Ceppi, Logan de Monchaux-Irons, Thor van Heesch, Alessia Sommer, Francesco Rivetti, Sung Sik Lee, Chiara Morelli, Paolo Arosio, Anna Sintsova, Thomas C. T. Michaels, Petr Ćejka, Jocelyne Vreede, Madhav Jagannathan
This study shows that nuclear mechanostability arises from satellite DNA condensation into chromocenters, which help dissipate mechanical stress and protect genome integrity.
bioRxiv · Aug 7, 2025 · PreprintCell Biology