Sung Sik Lee

Cdc42 Partitioning by Chaperone Ydj1 During Asymmetric Division and Aging in Yeast

The paper shows that Cdc42 accumulates in yeast mother cells over time, and Ydj1 helps distribute it unevenly to daughter cells, reducing aging in daughters.

Dissociation of the nuclear basket triggers chromosome loss in aging yeast

This study shows that nuclear basket displacement in aging yeast causes chromosome loss by disrupting pre-mRNA quality control and asymmetric segregation.

A protein condensation network contextualises cell fate decisions

The paper identifies a protein condensation network in yeast that integrates internal and external signals to regulate cell fate decisions during senescence and pheromone response.

Disruption of nucleolar integrity triggers cellular quiescence through organelle rewiring and secretion

This study identifies a stress response pathway linking nucleolar disruption to cellular quiescence and secretion, revealing its role in cancer progression.

Nuclear mechanostability emerges from satellite DNA condensation into chromocenters

This study shows that nuclear mechanostability arises from satellite DNA condensation into chromocenters, which help dissipate mechanical stress and protect genome integrity.

PKA regulates stress granule maturation to allow timely recovery after prolonged starvation

This paper shows that PKA-dependent phosphorylation drives stress granule maturation during prolonged starvation, delaying disassembly and promoting cell survival.

Positive feedback induces switch between distributive and processive phosphorylation of Hog1

The paper investigates the phosphorylation mechanism of Hog1 in yeast, finding that positive feedback enables a switch between distributive and processive phosphorylation, enhancing sensitivity and robustness.