Dose-related Mutagenic and Clastogenic Effects of Benzofluoranthene in Mouse Somatic Tissues Detected by Duplex Sequencing and the Micronucleus Assay
David M. Schuster, Danielle P. M. LeBlanc, Gu Zhou, Matthew J. Meier, Annette E. Dodge, Paul A. White, Alexandra S. Long, Andrew Williams, Cheryl A. Hobbs, Alex Diesing, Stephanie L. Smith‐Roe, Jesse J. Salk, Francesco Marchetti, Carole Lyn Yauk
This study assesses the mutagenic and clastogenic effects of benzo[b]fluoranthene in mice using Duplex Sequencing and the micronucleus assay, showing dose-dependent increases in mutation frequency and cancer-related mutation spectra.
Environmental Science & Technology · Nov 27, 2024Peer-reviewedPharmacology & Toxicology