Senescent myoblasts exhibit ROS-dependent Akt-mTORC1 dysregulation and are susceptible to reductive stress-induced cell death.
Vladimir Belhac, Alex Dillingham, Emilia Coward, Bradley Teal, Mark C. Turner, Stephanie D. Gagnon, Jiani Qian, Harry Wilford, Ella Warren, Natalie Moger, Bernadette Carroll, Owen G. Davies, Hannah F. Dugdale, Neil R. W. Martin
This study identifies ROS-dependent Akt-mTORC1 dysregulation in senescent myoblasts and shows antioxidants can suppress inflammation and promote differentiation but also induce cell death.
Aging Cell · Jun 1, 2026Peer-reviewedCell Biology