Author

Alex L. Nigg

Erasmus MC

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Andrea SacchettiiD· 1 shared Annemarie C. de Vries· 1 shared Eiman I. AhmediD· 1 shared Emily Middendorp Guerra· 1 shared Heba SaadehiD· 1 shared Jessica P RoelandsiD· 1 shared Karishma A. LilaiD· 1 shared Mathijs P. VerhageniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Andrea SacchettiORCID

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1 paper

Recent·Most cited

Inflammation-driven reprogramming of goblet cells underlies the onset of serrated adenomas in colon cancer

Mathijs P. Verhagen, Emily Middendorp Guerra, Rosalie Joosten, Andrea Sacchetti, Wenjie Sun, Karishma A. Lila, Alex L. Nigg, Eiman I. Ahmed, Heba Saadeh, Thierry P. P. van den Bosch, Wouter Hendrickx, Jessica P Roelands, Annemarie C. de Vries, Michail Doukas, Riccardo Fodde

The paper investigates how inflammation reprograms goblet cells into tumor-initiating cells in colon cancer using single-cell RNAseq and mutation spectrum analysis.

bioRxiv · Jun 23, 2026 · PreprintCancer Biology