Wenjie Sun

A combined program of induced stemness and differentiation in response to interferon gamma drives acute myeloid leukaemia growth

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

Clonal memory of cell division in humans diverges between healthy haematopoiesis and acute myeloid leukaemia

The paper shows clonal memory in human HSPCs persists across divisions and is disrupted in AML, with potential for therapeutic modulation.

Inflammation-driven reprogramming of goblet cells underlies the onset of serrated adenomas in colon cancer

The paper investigates how inflammation reprograms goblet cells into tumor-initiating cells in colon cancer using single-cell RNAseq and mutation spectrum analysis.

Genetic barcoding of individual cells links cancer evolutionary trajectories and prognostic outcomes

The paper uses genetic barcoding and single-cell transcriptomics to identify evolutionary trajectories in breast cancer cells, linking them to poor patient survival.

Common origin for effector and regulatory Follicular and Tissue-Adapted CD4+ T cells in Non-Small Cell Lung Cancer

The paper identifies a common origin for effector and regulatory CD4+ T cells in non-small cell lung cancer through single-cell analysis, revealing their plasticity and role in immune responses.

Humanized in vivo bone marrow models orchestrate multi-lineage human hematopoietic cell development

This study characterizes a humanized in vivo bone marrow model, hOss, showing its impact on human hematopoietic development and clonal interactions.

scMitoMut for calling mitochondrial lineage related mutations in single cells

scMitoMut is an R package that improves mitochondrial mutation calling in single cells by using statistical methods, showing better sensitivity and precision than existing tools.

Positional cues underlie cell fate specification during branching morphogenesis of the embryonic mammary epithelium

The paper uses single-cell RNA-sequencing to map the differentiation trajectories of mammary stem cells and identifies spatial and molecular features of lineage commitment during mammary branching morphogenesis.