Wouter Hendrickx

SLFN11 Enhances Cisplatin Sensitivity in Pediatric Cancer via Activation of Stress-Response and Suppression of Survival Pathways

This study shows SLFN11 enhances cisplatin sensitivity in pediatric cancers by modulating stress-response and survival pathways through epigenetic regulation and functional assays.

Inflammation-driven reprogramming of goblet cells underlies the onset of serrated adenomas in colon cancer

The paper investigates how inflammation reprograms goblet cells into tumor-initiating cells in colon cancer using single-cell RNAseq and mutation spectrum analysis.

Methylation-Guided Stratification of Colorectal Cancer Reveals Immune Subtypes with Distinct Clinical Outcomes

This study identifies immune subtypes of colorectal cancer using methylation patterns, linking them to distinct clinical outcomes and immune programs.

MUC2 Expression Modulates Immune Infiltration in Colorectal Cancer

This study investigates how MUC2 expression affects immune infiltration in colorectal cancer using in vitro models and CRISPR knockout, finding that MUC2 loss increases immune infiltration only in HT-29 cells.

Blood transcriptional module repertoire analysis and visualization using R

The paper provides R scripts for analyzing and visualizing blood transcriptional module repertoires, demonstrating their application in septic patients' transcriptome data.

The abundance of Nudix hydrolase 16 transcripts is elevated in human sepsis: perspectives gained during a hands-on reductionist investigation workshop.

The paper investigates NUDT16 transcript abundance in sepsis using omics data and public datasets, finding elevated levels in septic patients compared to controls.