Thierry P. P. van den Bosch

Behavior-coupled single-cell transcriptomics reveals trafficking protein-dependent regulation of tumor cell migration

This study introduces BC-seq, a method linking migratory behavior to transcriptomics in cancer cells, identifying molecular programs associated with aggressive migration and a predictive gene signature for metastasis.

Distinct roles for DNA- and RNA-sensing immune pathways in control of genital HSV-2 infection and restriction of neuroinvasion

This study shows that DNA- and RNA-sensing immune pathways differently control genital HSV-2 infection and prevent neuroinvasion.

Inflammation-driven reprogramming of goblet cells underlies the onset of serrated adenomas in colon cancer

The paper investigates how inflammation reprograms goblet cells into tumor-initiating cells in colon cancer using single-cell RNAseq and mutation spectrum analysis.

Impact of Enteric Neuronal Loss on Intestinal Cell Composition

This study investigates how loss of the enteric nervous system in zebrafish affects intestinal cell composition and identifies similar changes in human HSCR tissues.

Novel biomarkers in mutation-specific gene profiles highlight the involvement of COL9A3 in cancer cell plasticity in uveal melanoma

The paper identifies COL9A3 as a novel high-risk biomarker in uveal melanoma associated with cell plasticity and is most prevalent in BAP1mut tumors.

Transcriptional regulators FOXD1 and RBFOX2 contribute to metastatic capacity in BAP1mut uveal melanoma

This study investigates the role of transcription factors FOXD1 and RBFOX2 in BAP1mut uveal melanoma progression using knock-out and overexpression models, finding they influence tumor growth and dissemination.

A tug-of-war between the NuRD and SWI/SNF chromatin remodelers regulates the coordinated activation of Epithelial-Mesenchymal Transition and inflammation in oral cancer.

The paper shows that competition between NuRD and SWI/SNF chromatin remodelers regulates epithelial-mesenchymal plasticity and inflammation in oral cancer, with CDK2AP1 loss promoting pro-inflammatory responses and macrophage recruitment.

Integrative analysis of patient-derived tumoroids and ex vivo organoid modeling of ARID1A loss in bladder cancer reveals therapeutic molecular targets

The paper identifies CHEK1 and BIRC5 as therapeutic targets in ARID1A-deficient bladder cancer using patient-derived tumoroids and public datasets.