The chemorepellent effect of metformin limits bacterial penetration into mammalian mucus by altering bacterial motility
Kevin Simpson, Axel Ranson, Marta Vázquez-Gómez, Alex Le Guen, Aline Rifflet, Richard Wheeler, Héloïse Rytter, Clara Delaroque, Guy Gorochov, Benoît Chassaing, Tiphaine Le Roy, Ivo Gomperts Boneca, Éric Clément, Karine Clément
This study shows metformin acts as a bacterial chemorepellent, reducing bacterial penetration into mucus by altering motility and chemotaxis.
bioRxiv · Sep 18, 2026 · PreprintMicrobiology