Karine Clément

A Weight Loss Fibrotic Response in Visceral Fat Is Driven by Defective Lysosome-Dependent Collagenolysis

This study shows that weight loss fails to reverse visceral fat fibrosis due to impaired collagen degradation, suggesting ECM clearance enhancement as a therapeutic target.

The chemorepellent effect of metformin limits bacterial penetration into mammalian mucus by altering bacterial motility

This study shows metformin acts as a bacterial chemorepellent, reducing bacterial penetration into mucus by altering motility and chemotaxis.

Disruption of IgA-mediated aggregation at weaning favors mucus encroachment by commensal bacteria

This study shows that IgA-mediated bacterial aggregation at weaning prevents mucus penetration by commensal bacteria, while its disruption allows deeper bacterial encroachment.

Spatial characterization of microbiota profiles along the gut in a widely used mouse model: effects of high-fat diet and fructooligosaccharides

This study characterizes gut microbiota composition along the gastrointestinal tract in mice under high-fat diet and prebiotic conditions, revealing species-specific responses and challenges the translational relevance of rodent models.

Interpretable and accurate prediction models for metagenomics data

The paper develops interpretable metagenomics prediction models based on microbial taxon abundance ratios, additions, and subtractions, achieving performance comparable to or better than traditional machine learning methods.

The brain's hedonic valuation system's resting-state connectivity predicts weight loss and correlates with leptin

The paper examines how resting-state connectivity in the brain's hedonic valuation system predicts weight loss and correlates with leptin levels after gastric bypass surgery.

Microbiome Determinants and Physiological Effects of the Benzoate-Hippurate Microbial-Host Co-Metabolic Pathway

This study identifies microbiome determinants of hippurate, a metabolite linked to metabolic health, and demonstrates its protective effects in mice through benzoate-hippurate pathway analysis.

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

This study identifies genetic loci associated with early childhood growth phenotypes and links them to later adiposity traits, suggesting potential targets for obesity prevention.