The role of complex IV activity in the axonal response of mitochondria to demyelination in experimental disease models of multiple sclerosis
Simon Licht‐Mayer, Graham R. Campbell, Arpan R. Mehta, Katie McGill, Alex Symonds, Sarah Al‐Azki, Gareth Pryce, Stéphanie Zandee, Chao Zhao, Markus Kipp, Kenneth J. Smith, David Baker, Daniel R. Altmann, Stephen M. Anderton, Yolanda S. Kap, , Don Mahad
The paper assesses axonal mitochondrial content and complex IV activity in multiple experimental disease models of MS, finding that increased mitochondrial content does not always correlate with increased COX activity, and that COX activity inversely correlates with axonal injury.
Neuropathology and Applied Neurobiology · Oct 1, 2022Peer-reviewedNeuroscience