Markus Kipp

The paper identifies RIG-I-mediated innate immune activation in FUS-ALS spinal motor neurons due to mitochondrial dsRNA accumulation, which can be targeted by JAK-STAT inhibition, offering potential biomarker-driven treatment options.

This study shows that CREB knockout in Foxp3+ Tregs increases IL-10 and ST-2 expression, enhancing their suppressive function and preventing gut inflammation.

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

The paper assesses axonal mitochondrial content and complex IV activity in multiple experimental disease models of MS, finding that increased mitochondrial content does not always correlate with increased COX activity, and that COX activity inversely correlates with axonal injury.