David Baker

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

The paper assesses axonal mitochondrial content and complex IV activity in multiple experimental disease models of MS, finding that increased mitochondrial content does not always correlate with increased COX activity, and that COX activity inversely correlates with axonal injury.

This paper uses summary-data-based Mendelian randomisation to identify druggable genetic targets for multiple sclerosis, finding 15 genes with causal links between methylation, expression, and disease susceptibility.