Chao Zhao

The paper identifies BCL11A as a transcription factor that restores differentiation potential in aged oligodendrocyte progenitor cells through computational analysis and experimental validation.

The paper identifies integrin and BMP signaling pathways that drive OPC-to-SC differentiation in CNS regeneration using single-cell genomics.

This study identifies a retroviral origin of vertebrate myelin by showing that RNLTR12-int retrotransposon regulates myelination through SOX10 interaction in multiple vertebrates.

This study shows platelets modulate OPC differentiation during remyelination, with transient exposure promoting and sustained exposure inhibiting differentiation in a mouse model of MS.

The paper assesses axonal mitochondrial content and complex IV activity in multiple experimental disease models of MS, finding that increased mitochondrial content does not always correlate with increased COX activity, and that COX activity inversely correlates with axonal injury.

The paper compares the proteome of remyelination and developmental myelination in mice, finding distinct protein compositions and identifying potential therapeutic targets.

The paper shows that refeeding after fasting rapidly activates oligodendrocyte differentiation in the hypothalamic median eminence, altering extracellular matrix proteins and using mTORC1 signaling to monitor nutritional signals.

This study shows that microbiota modulates inflammatory responses during CNS demyelination but has little effect on remyelination in mice.