The Legionella pneumophila peptidoglycan recycling kinase, AmgK, is essential for survival and replication inside host alveolar macrophages
Sushanta Ratna, Lina Pradhan, Marina P. Vasconcelos, Aastha Acharya, Bella R. Carnahan, Alex Wang, Arit Ghosh, Abigail Bolt, Jacob Jacob Ellis, Stephen N. Hyland, Ashlyn S. Hillman, Joseph M. Fox, April M. Kloxin, M. Ramona Neunuebel, Catherine Leimkuhler Grimes
This study shows that AmgK, a peptidoglycan kinase in Legionella pneumophila, is essential for intracellular survival and replication in host macrophages, highlighting its role in pathogenicity and potential as a drug target.
bioRxiv · Mar 21, 2025 · PreprintMicrobiology