Author

April M. Kloxin

University of DelawareORCID 0000-0002-4594-2953Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 3 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Bryan P. SutherlandiD· 2 shared Lina PradhaniD· 2 shared Samantha E. CasseliD· 2 shared Samantha L. SwedzinskiiD· 2 shared Aastha Acharya· 1 shared Abigail BoltiD· 1 shared Alex Wang· 1 shared Arit GhoshiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

Bryan P. SutherlandORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Commensal Engineered Living Materials for Sustained Secretome Delivery and Wound Healing

Claire O Lois, Elizabeth A Grice, April M Kloxin, Millicent O Sullivan

This paper develops a commensal Engineered Living Material (cELM) that encapsulates bacteria to deliver a pro-healing secretome for chronic wound healing.

bioRxiv · Nov 6, 2026 · PreprintBioengineering

Thermoresponsive, Shear-Thinning Supramolecular Hydrogels from Peptide-Polymer Conjugates for Bioinspired 3D Cell Culture

Breanna M. Huntington, Johannes A. Dresel, Maren Schweitzer, Eric M. Furst, Pol Besenius, April M. Kloxin

This paper develops thermoresponsive, shear-thinning supramolecular hydrogels from peptide-polymer conjugates for 3D cell culture, showing good cell viability and material stability.

bioRxiv · Sep 9, 2026 · PreprintBioengineering

Matrix stiffening toolbox: dynamic hydrogels for three-dimensional cell culture with real-time cell response

Eden M. Ford, Samantha E. Cassel, Bryan P. Sutherland, Samantha L. Swedzinski, April M. Kloxin

This paper introduces a dynamic hydrogel platform to study cell responses to matrix stiffening, showing increased alpha-smooth muscle actin expression and altered fibroblast motility during early fibrosis.

bioRxiv · Mar 28, 2026 · PreprintBioengineering

Probing Critical Injury Thresholds for Maladaptive Epithelial Injury and Repair Processes with Photoresponsive Bioinspired Synthetic Basement Membrane

Lina Pradhan, Bryan P. Sutherland, Samantha L. Swedzinski, Kartik Bomb, Qi Zhang, Samantha E. Cassel, Catherine A. Fromen, April M. Kloxin

This study develops a photoresponsive synthetic basement membrane to investigate injury and repair processes in epithelial cells, finding that critical injury sizes lead to dysregulated re-epithelialization.

bioRxiv · Dec 26, 2025 · PreprintBioengineering

The Legionella pneumophila peptidoglycan recycling kinase, AmgK, is essential for survival and replication inside host alveolar macrophages

Sushanta Ratna, Lina Pradhan, Marina P. Vasconcelos, Aastha Acharya, Bella R. Carnahan, Alex Wang, Arit Ghosh, Abigail Bolt, Jacob Jacob Ellis, Stephen N. Hyland, Ashlyn S. Hillman, Joseph M. Fox, April M. Kloxin, M. Ramona Neunuebel, Catherine Leimkuhler Grimes

This study shows that AmgK, a peptidoglycan kinase in Legionella pneumophila, is essential for intracellular survival and replication in host macrophages, highlighting its role in pathogenicity and potential as a drug target.

bioRxiv · Mar 21, 2025 · PreprintMicrobiology