M. Ramona Neunuebel

The paper identifies 33 novel phosphoinositide-binding effectors from three intracellular pathogens, revealing conserved α-helical structural motifs distinct from eukaryotic lipid-binding domains.

This study shows that AmgK, a peptidoglycan kinase in Legionella pneumophila, is essential for intracellular survival and replication in host macrophages, highlighting its role in pathogenicity and potential as a drug target.