ESCRT-III accumulates in micronuclei with ruptured nuclear envelopes
Jessica Willan, Alexa Cleasby, Neftali Flores-Rodriguez, Flavia Stefani, Cinzia Rinaldo, Alessandra Pisciottani, Emma Grant, Philip Woodman, Helen Bryant, Barbara Ciani
This study shows ESCRT-III and CHMP7 protect against genomic instability in micronuclei by repairing nuclear envelopes but also generate cytosolic DNA that promotes inflammation in cancer cells.
bioRxiv · Dec 1, 2018 · PreprintCancer Biology