Pathological tau leads to network hyperexcitability through neuronal-subtype-specific functional impairment
Changyi Ji, Yunlu Zhu, Hediye Erdjument‐Bromage, Soomin C. Song, Natalie Chang, Amanda R Liu, Alexa R Lee, Olivia A. DeGulis, David Schoppik, Thomas A. Neubert, Hyung Don Ryoo, Einar Sigurdsson
This study shows that the MAPT P301L mutation causes neuronal network hyperexcitability through subtype-specific tau pathology and altered synaptic transmission.
bioRxiv · Oct 6, 2026 · PreprintNeuroscience